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COMPOSITIONS AND METHODS OF TREATMENT AND / OR PREVENTION OF CARDIOVASCULAR DISEASE
专利权人:
ИНК. (US);АМАРИН ФАРМА
发明人:
РОУ Джонатан (US)
申请号:
RU2012142181/13
公开号:
RU2012142181A
申请日:
2011.03.04
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of increasing the level of EPA in plasma and / or serum in a patient in need thereof, comprising administering to the patient a daily pharmaceutical composition comprising at least 96% by weight of ethyl eicosapentaenoate, from about 0.2% to about 0.5% by weight ethyl octadecatetetraenoate, from about 0.05% to about 0.25% by weight of ethyl nanoecapentaenoate, from about 0.2% to about 0.45% by weight of ethyl arachidonate, from about 0.3% to about 0.5% by weight of ethyl eicosatetraenoate, from about 0.05% to at Relatively 0.32% ethylgenecosapentaenoate and not more than 0.05% ethyl DHA, if present, in an amount sufficient to increase the patient’s plasma and / or serum EPA levels by at least about 200% compared to the initial one. 2. The method according to claim 1, wherein the composition is administered in an amount sufficient to increase the patient's plasma EPA levels and / or serum by at least 300% compared to the initial one. The method of claim 1, wherein the composition is administered in an amount sufficient to increase the patient’s plasma and / or serum EPA levels by at least 400% compared to the initial. The method of claim 3, wherein the composition is administered to a patient daily for at least about 6 weeks. The method of claim 4, wherein the initial level of EPA in the plasma and / or serum of the patient is not more than about 50 μg / ml. The method according to claim 1, wherein when 2 g of the composition is administered to the patient daily for at least about 6 weeks, the patient exhibits at least a 200% increase in the level of EPA in plasma and / or serum compared to the initial one. The method according to claim 1, where with the introduction of 4 g of the composition of the patient1. Способ повышения уровня EPA в плазме и/или сыворотке у пациента, нуждающегося в этом, включающий введение пациенту ежедневно фармацевтической композиции, включающей по меньшей мере 96% по массе этилэйкозапентаеноата, от приблизительно 0,2% до приблиз
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