A method for simulating and correcting deformation of cerebral tissue images comprises the following steps: separating the cerebral tissue from a skull by using an automatic segmenting method based on level set performing multi-resolution meshing for the result of the segmentation, so as to obtain the segmented tetrahedral meshes with a higher density near boundaries and with a lower density inside enduing every mesh unit with corresponding biomechanical attributes, and establishing a linear elastic model of the cerebral tissue aligning a 3D laser scanner for texture imaging with the opening region of the skull and carrying out scanning, acquiring point cloud data of the deformed cortical surface, and calculating displacements of surface nodes by surface tracking algorithm as the boundary condition of finite element calculation according to the acquired boundary condition, calculating the deformation field of the whole cerebral tissue by finite element method and updating pre-operative images by reverse interpolation, and carrying out 3D visualization by surface projection algorithm.
