The present invention relates to the determination of brain deformation. The invention relates in particular to a device for tracking brain deformation, an imaging system for tracking brain deformation, a method for tracking brain deformation, a method of operating a device for tracking brain deformation, as well as to a computer program element and a computer readable medium. For providing enhanced information about the brain deformation, a first 3D representation (112) of a cerebrovascular vessel structure of a region of interest of an object is provided (110) and (114) a second 3D representation (116) of the cerebrovascular vessel structure. Then, at least a part of the first 3D representation is elastically three dimensionally registered (118) with at least a part of the second 3D representation. A deformation field (122) of the cerebrovascular vessel structure is determined (120) based on the elastic registration. The determined vessel deformation is applied (124) to a brain structure representation to determine a deformation (126) of the cerebral structure. For example, planning data (130) for an intervention of the cerebral structure is provided (132) and the determined deformation of the cerebral structure is applied (134) to the planning data to generate deformation adjusted planning data (136).
