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Fusion Products of Aminated Polysaccharides
专利权人:
Б. БРАУН МЕЛЬЗУНГЕН АГ (DE)
发明人:
МАЙЕР Бернд Хорст (DE),ЯНКОВИАК-МАЙЕР Ирис (DE),МАЙЕР Неле (DE),МАЙЕР Клара (DE)
申请号:
RU2011143812/15
公开号:
RU2011143812A
申请日:
2010.03.31
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A fusion product that includes at least polysaccharides T1 and T2, characterized in that a) the monosaccharides from which the polysaccharides T1 and T2 are formed are partially or fully linked to each other by alpha-1,4-glycosidic bonds, and b) at least at least one of the polysaccharides T1 and / or T2 has at least one amino group, c) T1 and T2 are connected to each other via at least one bonding element Z by a chemical covalent bond, and d) T1 and / or T2 contains m groups - ( LA), wherein A is a drug active substance and / or fluo a recession marker, L is the second binding element by which T1 and / or T2 are covalently linked to A, and m is an integer that may be 0 or at least 1.2. The fusion product according to claim 1, characterized in that the polysaccharides T1 and T2 are independently selected from the group consisting of aminated hydroxyethyl starch, aminated carboxymethyl starch, aminated carboxyethyl starch, aminorinated hydroxyethyl starch and aminated hydroxyalkyl. The fusion product according to claim 1, characterized in that the polysaccharides T1 and / or T2 have amino groups which are introduced by reductive amination. The fusion product according to claim 1, characterized in that the polysaccharides T1 and / or T2 have at least one —NH group. The fusion product according to claim 1, characterized in that the monosaccharides from which the polysaccharides T1 and T2 are formed are bonded to each other by an alpha-1,4-glycosidic linkage of at least 20%, preferably at least 50%, particularly preferably at least 90% in relation to the total number of monosaccharides. 6. The merger product according to claim 1, from1. Продукт слияния, который включает по меньшей мере полисахариды Т1 и T2, отличающийся тем, чтоa) моносахариды, из которых образованы полисахариды Т1 и T2, частично или полностью соединены друг с другом альфа-1,4-гликозидными связями, иb) по меньшей мере один из полисахаридов Т1 и/или T2 имеет по меньшей мере одну аминогруппу, иc) Т1 и
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