ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НАУЧНО-ПРОИЗВОДСТВЕННЫЙ ЦЕНТР "АМФИОН" (RU)
发明人:
Архипов Антон Борисович (RU),Артюхов Александр Анатольевич (RU),Дементьев Дмитрий Давидович (RU),Штильман Михаил Исаакович (RU),Наумиди Татьяна Леонидовна (RU)
申请号：
RU2014154395
公开号：
RU2014154395A
申请日:
2014.12.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The hydrogel material is obtained by polymerization in a solution containing a mixture of unsaturated derivatives of polyvinyl alcohol of general formula (I) and unsaturated derivatives of 2-hydroxyethyl starch of formula (II) wherein R is independently selected from -H, -CH2CH2OH R1 is -OH R2 is -O-CO-R4, where R4 represents -CH3 or the residue of another acid, polyvinyl alcohol wherein the polyvinyl ester was obtained R3 is an unsaturated group independently selected izCH2 = CH-CO-O-, CH2 = C (CH3) -CO-O-, CH3-CH = CH-CH = CH-CO-O-, CH3-CH = CH-CO-O-, C6H5 -CH = CH-CO-O-, CH2 = C (CH3) -CO-O-CH2-CH (OH) -CH2-O-, CH2 = CH-CO-O-CH2-CH (OH) -CH2- O-CH2 = CH-O-, CH2 = CH-CH2-O- or CH2 = CH-O-CH2-CH2-O- R5 is -H, -CH2CH2OH or R6 represents -H, -CH2CH2OH or - CH2CH2OCH2CH2OH R7 represents soboy- -R3, -CH2CH2R3 or -CH2CH2OCH2CH2R3. m = 85-98 mole%, n = 0,1-12 mol%, k = 0,5-25 mol%.. for unsaturated derivatives of 2 -gidroksietilkrahmala general formula (II) the number of units containing unsaturated radicals is from 0.5 to 95 mol.%. 2. Hydrogel material according to claim 1, wherein the ratio between unsaturated derivatives of polyvinyl alcohol, and 2-hydroxyethyl starch is from 99.9 / 0.1 to 0.1 / 99.9 wt.%. 3. Hydrogel material according to claim 1, characterized in that the formation of the hydrogels is carried out in vivo by injecting a solution of polymers of the general formula (I) and (II), further comprising a nontoxic initsiator.4. Hydrogel material according to any one of claims 1-3, wherein the medicament further comprises sredstvo.5. Hydrogel material according to claim 4, characterized in that the medicament contains an antiseptic or an antibiotic, such as gentamycin, lincomycin, rifampicin or hlorgeksidin.6. Hydrogel material according to claim 4, characterized in that the medicament comprises a local anesthetic, e.g. lidokain.7. Hydrogel material according to claim 4, wherein the h1. Гидрогелевый материал, полученный путем проведения полимеризации в рас
