The present application relates to novel heterocyclically substituted 6-(trifluoromethyl)pyrimidin-4(3H)-one derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.本申請案係有關一種新穎之雜環經取代之6-(三氟甲基)嘧啶-4(3H)-酮衍生物、其製法、其單獨或組合用於治療及/或預防疾病之用途、及其於製備供治療及/或預防疾病(特定言之供治療及/或預防心血管、腎、發炎與纖維變性疾病)之醫藥上之用途。