The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.本申請案係有關一種新穎之經取代之六氫吡啶基四氫喹啉、其製法、其於治療與/或預防疾病上之用途、及其於製備用於治療與/或預防疾病之醫藥上之用途，特定言之用於治療與/或預防糖尿病微血管病變、糖尿病性肢端潰爛，特定言之用於促進糖尿病性足部潰爛傷口癒合、糖尿病性心臟衰竭、糖尿病性微血管心絞痛、周邊及心血管疾病、血栓性栓塞疾病及局部缺血、末梢循環不良、雷諾氏症候群(Raynaud’s phenomenon)、CREST症候群、微循環障礙、間歇性跛行、及周邊與自律神經病變。
