Provided is a humanized monoclonal antibody or a fragment thereof that selectively inhibits the enzymatic activity of vascular endothelial lipase and pharmaceutical compositions containing the same as an active ingredient useful for the treatment of arteriosclerosis or metabolic syndrome.本發明提供一種對動脈硬化或新陳代謝症候群之治療有效之選擇性地阻礙血管內皮脂酶活性的人類化單株抗體或其抗體片段、及包含該等作為有效成分之醫藥組合物。