THE UNITE STATES OF AMERICA AS REPRESENTED BY UNTED STATES
DEPARTMENT OF VETERANS AFFAIRS;FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY
SCHOOL OF MEDICINE;LOMA LINDA UNIVERSITY
发明人:
Zhang XIAOBING,Wanqui CHEN,David BAYLINK,Kin-Hing William LAU
申请号:
US17256509
公开号:
US20210177908A1
申请日:
2019.06.28
申请国别(地区):
US
年份:
2021
代理人:
摘要:
In one aspect, anabolic agent fusion proteins and compositions comprising anabolic agent fusion proteins are provided. In some embodiments, the anabolic agent fusion protein comprises a platelet derived growth factor (PDGF) or a fibroblast growth factor (FGF) and an Asp-Ser-Ser tripeptide (DSS) repeat sequence. In another aspect, methods of promoting bone growth and methods of treating a fracture using anabolic agent fusion proteins and compositions comprising anabolic agent fusion proteins are provided.