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КОМПОЗИЦИИ РОТИГОТИНА, ИХ ПРОИЗВОДНЫХ ИЛИ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ РОТИГОТИНА ИЛИ ИХ ПРОИЗВОДНЫХ
专利权人:
ШАН ДОНГ ЛЮИЕ ФАРМАЦЕУТИКАЛ КО.; ЛТД (CN)
发明人:
ВАНГ Аипинг (CN),ЛИ Йоуксин (DE),ЛИУ Ванхуи (CN),СУН Каоксианг (CN),ЛИ Жун (CN),СУН Лифанг (CN)
申请号:
RU2013128430/15
公开号:
RU2013128430A
申请日:
2011.11.25
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Composition based on rotigotine or a pharmaceutically acceptable salt thereof, characterized in that it comprises at least one polylactide-glycolide (PLGlA) and at least one fatty acid with at least one fatty acid is about 1-15 wt.% of the total weight sostava.2. A composition according to claim 1, characterized in that it is in the form mikrosfer.3. A composition according to claim 2, characterized in that the rotigotine or a pharmaceutically acceptable salt thereof constitute 20-40 wt.% Of the total weight sostava.4. A composition according to claim 3, characterized in that at least one PLGlA is about 45-79 wt.% Of the total weight sostava.5. A composition according to claim 4, characterized in that the pharmaceutically acceptable salt formed with an inorganic or organic kislotoy.6. A composition according to claim 5, characterized in that the inorganic acid is selected from the list of: hydrochloric acid, sulfuric acid, phosphoric acid and nitric kislota.7. A composition according to claim 5, characterized in that the organic acid is selected from the list of: citric acid, fumaric acid, maleic acid, acetic acid, benzoic acid, lactic acid, metapsulfonovaya acid, naphthalenesulfonic acid and toluene-n-sulfonic kislota.8. A composition according to claim 5, characterized in that the organic acid - acidic amino acid selected from the list: glutamic acid and aspartic kislota.9. A composition according to claim 4, characterized in that the rotigotine or a pharmaceutically acceptable salt thereof, constitute 20-40% of at least one PLGlA is 57.5-72.5% and the fatty acid is 2.5-7.5% of the total weight sostava.10. The composition according to claim 9, characterized in that1. Композиция на основе ротиготина или его фармацевтически приемлемой соли, характеризующаяся тем, что содержит, по крайней мере, один полилактид-гликолид (ПЛГлА) и по крайней мере, одну жирную кислоту, причем, по крайней мере, одна жирная кислота составляет порядка 1-15 вес.% от общей массы состава.2
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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