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СПОСОБЫ СИНТЕЗА ПРОИЗВОДНЫХ ДИГИДРОПИРИДОФТАЛАЗИНОНА
专利权人:
БАЙОМАРИН ФАРМАСЬЮТИКАЛ ИНК. (US)
发明人:
ВАН Бин (US),ЧУ Дэниэл (US),ЛЮ Юнбо (CN),ЦЗЯН Цюань (CN),ЛЮ Лей (CN)
申请号:
RU2012138345/04
公开号:
RU2012138345A
申请日:
2011.02.08
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A process for preparing a compound of formula (1): or a salt thereof, comprising: reacting a compound of formula (5) or a salt thereof, with hydrazine monohydrate, where R is a C-Calkil.2. A method according to claim 1, wherein the compound of formula (5) or its salt is prepared by reacting a compound of formula (4): or its salt with 4-fluorobenzaldehyde in the presence of a reducing agent and an acid or Lewis acid, wherein R is a C-Calkil.3. A method according to claim 2, wherein the reducing reagent is a halide metalla.4. A method according to claim 3, wherein the metal halide is TiClili SnCl.5. A method according to claim 2, wherein the reducing agent is a powder Fe.6. A method according to claim 2, wherein the reducing agent is hydrogen in the presence of a metal katalizatora.7. A method according to claim 6, wherein the metal catalyst is selected from the group consisting of palladium, nickel and platiny.8. A method according to claim 2, wherein the reducing agent is MCNBH, wherein M is selected from the group consisting of Li, Na, K, and BuN.9. A method according to claim 2, wherein the acid is an inorganic acid selected from the group consisting of HCl, HBr, HI, HSOi HPO.10. A method according to claim 2, wherein the acid is an organic acid selected from the group consisting of formic acid, acetic acid, propionic acid, butyric acid, trifluoroacetic acid, p-toluenesulfonic acid, and methylsulfonic kisloty.11. A method according to claim 2, wherein the Lewis acid is selected from the group consisting of AlCl, TiCl, SnCli ZnCl.12. A method according to claim 2, wherein the compound of formula (4) or its salt is prepared by treating a compound of formula (3): or a salt thereof Preece compound R-OH1. Способ получения соединения формулы (1):или его соли, включающий:взаимодействие соединения формулы (5),или его соли, с моногидратом гидразина, где R представляет собой C1-C 6 алкил.2. Способ по п.1, где соединение формулы (5) или его соль получают взаимодействием с
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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