СТЕЛЛА Марк Эдвард (US),ЕНТВИСЛЕ Джон Ричард (US),НЬЮЛОН Джейсон Уильям (US),НАЙККИ Кристин Луи (US)
申请号：
RU2014149581
公开号：
RU2014149581A
申请日:
2013.06.12
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. An effervescent chewable dosage form comprising: a. from about 26% to about 40% pH of the neutralizing agent； b. from about 3% to about 10% acid； c. from about 3% to about 10% of an effervescent agent. 2. The effervescent chewable dosage form according to claim 1, characterized in that the pH neutralizing agent is calcium carbonate. The effervescent chewable dosage form according to claim 1, characterized in that the acid is citric acid. The effervescent chewable dosage form according to claim 1, characterized in that the effervescent agent is sodium bicarbonate. The effervescent chewable dosage form according to claim 1, characterized in that it further comprises from about 0.3% to about 1% of a lubricant. The effervescent chewable dosage form according to claim 1, characterized in that it further comprises simethicone. The effervescent chewable dosage form according to claim 1, characterized in that it further comprises from about 35% to about 50% sweetener. The effervescent chewable dosage form according to claim 1, characterized in that the destructive force for the tablet is from about 4 kgf to about 8.5 kgf. The effervescent chewable dosage form according to claim 1, characterized in that the pH value at equilibrium is from about 6.5 to about 9.5.10. The effervescent chewable dosage form according to claim 1, characterized in that the pH value after 2 minutes is from about 3 to about 6.11. The effervescent chewable dosage form according to claim 1, characterized in that the ratio of the solubility in water of the effervescent agent and the pH of the neutralizing agent is more than about 10000: 1.12. Effervescent chewing l1. Шипучая жевательная лекарственная форма, содержащая:a. от приблизительно 26% до приблизительно 40% рН нейтрализующего агента；b. от приблизительно 3% до приблизительно 10% кислоты； иc. от приблизительно 3% до приблизительно 10% шипучего агента.2. Шипучая жевательная лекарственная форма по п. 1, отличающаяся тем, что рН нейтрализующий аген
