THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人:
LILLICO, SIMON GEOFFREY,ARCHIBALD, ALAN,WHITELAW, CHRISTOPHER BRUCE ALEXANDER,TAIT-BURKARD, CHRISTINE,AIT-ALI, TAHAR
申请号：
CA3037451
公开号：
CA3037451A1
申请日:
2017.10.17
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to genetically edited swine which produce CD163 protein in which the scavenger receptor cysteine-rich 5 (SRCR5) domain (also known as CD163 domain 5) has been deleted. Such swine have been found to be healthy and do not exhibit negative properties, and are resistant to PRRSV infection. CD163 expressed in the edited swine also demonstrates retention of the ability to function as a haemoglobin-haptoglobin scavenger. Methods of producing such swine are also provided.
