Langermann, Solomon,Podojil, Joseph R.,Miller, Stephen D.
申请号：
AU2014265142
公开号：
AU2014265142A1
申请日:
2014.05.19
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
Isolated cell surface receptors for B7-H4 have been identified based on function. B7-H4 receptor activation by B7-H4 on the dendritic cell, T follicular helper cell and germinal center B cell membrane stimulates inhibitory signaling in those leukocytes. B7-H4 receptor activation decreases production and/or secretion of proinflammatory cytokines, and promotes anti-inflammatory cytokine by mature DC and T cells. Modulators of B7-H4 receptor polypeptides and methods for their therapeutic use are also provided.
