The University Court of the University of Edinburgh
发明人:
Simon Geoffrey Lillico,Alan Archibald,Christopher Bruce Alexander Whitelaw,Christine Tait-Burkard,Tahar Ait-Ali
申请号：
US16342650
公开号：
US20200045945A1
申请日:
2017.10.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to genetically edited swine which produce CD163 protein in which the scavenger receptor cysteine-rich 5 (SRCR5) domain (also known as CD163 domain 5) has been deleted. Such swine have been found to be healthy and do not exhibit negative properties, and are resistant to PRRSV infection. CD163 expressed in the edited swine also demonstrates retention of the ability to function as a haemoglobin-haptoglobin scavenger. Methods of producing such swine are also provided.
