ISSAACS, BENJAMIN S.,ALLAN, CHRISTIAN B.,CHANG, STEPHEN,SHANE, ERICA,OLIVER, CYNTHIA N.
申请号：
AU2013201261
公开号：
AU2013201261A1
申请日:
2013.03.05
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS Abstract The present invention provides liquid formulations of SYNAGIS* or an antigen binding fragment thereof that immunospecifically bind to a respiratory syncytial virus 5 (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS* or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS* or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations 10 are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.
