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STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS
专利权人:
MedImmune; LLC
发明人:
Cynthia N. Oliver,Erica Shane,Benjamin S. Isaacs,Christian B. Allan,Stephen T. Chang
申请号:
US15852023
公开号:
US20180230202A1
申请日:
2017.12.22
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.
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