Stephen T. Chang;Erica Shane;Christian B. Allan;Cynthia N. OLIVER;Benjamin S. Isaacs
发明人:
Cynthia N. OLIVER,Erica Shane,Benjamin S. Isaacs,Christian B. Allan,Stephen T. Chang
申请号：
US13481640
公开号：
US20120321616A1
申请日:
2012.05.25
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.
