COLLER BETH ANN GRISWOLD,PAI VIDYA B,PARKS D ELLIOT,YELMENE MICHELE,BETT ANDREW J,MARTYAK TIMOTHY
申请号：
IN2970/CHENP/2013
公开号：
IN2013CN02970A
申请日:
2013.04.17
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention provides dengue virus vaccines and immunogenic compositions for administration to human subjects. The vaccine compositions of the present invention comprise recombinantly produced monomeric and/or dimeric forms of truncated dengue virus envelope glycoprotein that when formulated together with an adjuvant and a pharmaceutically acceptable carrier induce balanced tetravalent immune responses. In preferred embodiments of the compositions described herein the DEN4 protein component is a dimeric form of DEN4. The compositions are designed to be acceptable for use in the general population including immunosuppressed immunocompromised and immunosenescent individuals. Also provided herein are methods of inducing a protective immune response in a human patient population by administering the compositions described herein to the patients.
