Andrew J. Bett;Timothy Martyak;D. Elliot Parks;Beth-Ann Griswold Coller;Vidya B. Pai;Michele Yelmene
发明人:
Beth-Ann Griswold Coller,Vidya B. Pai,D. Elliot Parks,Michele Yelmene,Andrew J. Bett,Timothy Martyak
申请号：
US13881423
公开号：
US09198964B2
申请日:
2011.10.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides dengue virus vaccines and immunogenic compositions for administration to human subjects. The vaccine compositions of the present invention comprise recombinantly produced monomeric and/or dimeric forms of truncated dengue virus envelope glycoprotein that, when formulated together with an adjuvant and a pharmaceutically acceptable carrier, induce balanced tetravalent immune responses. In preferred embodiments of the compositions described herein, the DEN4 protein component is a dimeric form of DEN4. The compositions are designed to be acceptable for use in the general population, including immunosuppressed, immunocompromised, and immunosenescent individuals. Also provided herein are methods of inducing a protective immune response in a human patient population by administering the compositions described herein to the patients.
