Coller, Beth-Ann Griswold,Pai, Vidya B.,Parks, D. Elliot,Yelmene, Michele,Bett, Andrew J.,Martyak, Timothy
申请号：
AU2011367817
公开号：
AU2011367817A1
申请日:
2011.10.27
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The present invention provides dengue virus vaccines and immunogenic compositions for administration to human subjects. The vaccine compositions of the present invention comprise recombinantly produced monomeric and/or dimeric forms of truncated dengue virus envelope glycoprotein that, when formulated together with an adjuvant and a pharmaceutically acceptable carrier, induce balanced tetravalent immune responses. In preferred embodiments of the compositions described herein, the DEN4 protein component is a dimeric form of DEN4. The compositions are designed to be acceptable for use in the general population, including immunosuppressed, immunocompromised, and immunosenescent individuals. Also provided herein are methods of inducing a protective immune response in a human patient population by administering the compositions described herein to the patients.
