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צורות מינון מוצקות עם שחרור מושהה של אונדנסטרון לטיפול בתסמינים של בחילות, שלשולים או הקאות
专利权人:
RedHill Biopharma Ltd.
发明人:
申请号:
IL24769816
公开号:
IL247698D0
申请日:
2016.09.08
申请国别(地区):
IL
年份:
2016
代理人:
摘要:
A method of treating a patient comprises orally administering a solid oral dosage form comprising a core comprising a non-ionic polymer matrix, a first amount of ondansetron dispersed within the matrix, and a salt dispersed within the matrix, wherein the first amount of ondansetron ranges from about 9 mg to about 28 mg; a first seal coat surrounding the core, wherein the first seal coat is comprised of a non-ionic polymer matrix; and an immediate release drug layer surrounding the first seal coat and comprising a non-ionic polymer and a second amount of ondansetron dispersed therein, wherein the second amount of ondansetron ranges from about 3 mg to about 8 mg, wherein release of ondansetron from the solid oral dosage form provides exposure to ondansetron for a minimum period of 16 hours so as to result in a reduction in frequency of vomiting, nausea, diarrhea, or a combination thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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