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pharmaceutical dosage form, and method for preparing a solid dosage form.
专利权人:
ABBOTT GMBH & CO. KG
发明人:
BERND LIEPOLD,CLAUDIA PACKHÄUSER,JÖRG BREITENBACH,MARKUS MÄGERLEIN,THOMAS KESSLER
申请号:
BRPI0914918
公开号:
BRPI0914918A2
申请日:
2009.06.30
申请国别(地区):
BR
年份:
2015
代理人:
摘要:
A pharmaceutical dosage form comprises a solid dispersion product of at least one active ingredient dispersed in a polymeric binder composition, the polymeric carrier composition comprising a) a vinylpyrrolidone homopolymer, wherein at least 95 % by weight of the vinylpyrrolidone homopolymer has a molecular weight distribution within the range of from 1000 to 13 000; and b) a vinylpyrrolidone copolymer having a weight-average molecular weight of from 5000 to 1 500 000. The dosage form is preferably prepared by a melt extrusion process. The polymeric carrier composition exhibits a high drug dissolution power and allows a reduction of the viscosity of the melt without deteriorating the mechanical properties and storage stability of the dosage form.
来源网站:
中国工程科技知识中心
来源网址:
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