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controlled release pharmaceutical formulation and method.
专利权人:
THE UNIVERSITY OF TEXAS SYSTEM;UNIV TEXAS;BOARD OF REGENTS
发明人:
JAMES W. MCGINITY,SANDRA SCHILLING,MCGINITY JAMES W,SCHILLING SANDRA
申请号:
BRPI0917358
公开号:
BRPI0917358A2
申请日:
2009.08.20
申请国别(地区):
BR
年份:
2015
代理人:
摘要:
The present invention includes compositions and methods of making a modified release pharmaceutical formulation and a method of preparation for the embedding of modified release multi-particulates into a polymeric or wax-like matrix. The modified release multi-particulates comprise an effective amount of a therapeutic compound having a known or desired drug-release profile. Modified release multi-particulates may include a polymeric coat or may be incorporated into particle or core material. The polymer matrix comprises a thermoplastic polymer or lipophilic carrier or a mixture thereof that softens or melts at elevated temperature and allows the distribution of the modified release multi-particulates in the polymer matrix during thermal processing. Formulation compounds and processing conditions are selected in a manner to preserve the controlled release characteristics and/or drug-protective properties of the original modified release multi-particulates.
来源网站:
中国工程科技知识中心
来源网址:
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