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MOBILISATION OF TRANSPOSABLE ELEMENTS TO ENHANCE GENETIC AND EPIGENETIC VARIABILITY IN A POPULATION
专利权人:
UNIVERSITAT BASEL
发明人:
BUCHER, ETIENNE,THIEME, MICHAEL
申请号:
CA3006632
公开号:
CA3006632A1
申请日:
2016.11.30
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
A method for the mobilization of a transposable element is provided. The method comprises the steps of a) providing an inhibitor of DNA methylation, and/or an inhibitor of transcription, and b) contacting the inhibitor(s) with a cell comprising inactivated transposable elements, yielding a cell with mobilized transposable elements. In a second aspect of the invention a method for increasing the genetic and/or epigenetic variation in a plurality of eukaryotic organisms is provided. The method comprises the steps of i. providing an inhibitor of DNA methylation and/or an inhibitor of transcription, ii. contacting the organism with the inhibitor(s) and iii. propagating the organism.
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中国工程科技知识中心
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