The present invention provides a kind of methods for making transposable element move.It the described method comprises the following steps:A) DNA methylation inhibitor and/or transcription inhibitor are provided and b) contact the inhibitor and the cell of the transposable element comprising inactivation, to generate the cell with mobile transposable element.In the second aspect of the present invention, a kind of provide the hereditary variation increased in multiple eucaryotic organism bodies and/or epigenetic variation method.It the described method comprises the following steps:I. DNA methylation inhibitor and/or transcription inhibitor are provided, ii. makes that the organism contacts with the inhibitor and iii. makes the organism breeding.
