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Methods for the treatment and improvement of cognition of Alzheimer's disease
专利权人:
ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート
发明人:
アルコン、ダニエル・エル.,アルコン、ダニエル・エル.
申请号:
JP2007531176
公开号:
JP5638735B2
申请日:
2005.08.10
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
The present invention relates to compositions comprising a combination of PKC activators and PKC inhibitors and methods to modulate α-secretase activity; improve or enhance cognitive ability; and/or reduce neurodegeneration in individuals suffering from diseases that impair cognitive ability, particularly Alzheimer's Disease. The invention also relates to methods for improving or enhancing cognitive ability. The present invention also provides methods for increasing the generation of non-amyloidogenic soluble APP (sAPP) comprising the activation of protein kinase C (PKC) in the brain and inhibiting PKC in peripheral tissues. Macrocyclic lactones (i.e. bryostatin class and neristatin class) are preferred PKC activators and Vitamin E is a preferred PKC inhibitor for use in the inventive composition.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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