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Therapeutic agent for neurodegenerative disease
专利权人:
Hiroyoshi Ariga
发明人:
Hiroyoshi Ariga
申请号:
US12085424
公开号:
US08318798B2
申请日:
2006.11.17
申请国别(地区):
US
年份:
2012
代理人:
摘要:
[Problems] To provide a neuronal cell death inhibitor and a therapeutic agent for a neurodegenerative disease, particularly Parkinson's disease.[Means for Solving Problems] It is known that DJ-1 protein is involved in Parkinson's disease and is capable of inhibiting neuronal cell death caused by oxidative stress. Based on this knowledge, screening is made for a low molecular weight molecule capable of binding to an active site of DJ-1 protein (i.e., a region around a cysteine residue at position-106) using an analysis softwear FastDock (Fujitsu Ltd.). When various tests are made using candidate low molecular weight compounds each having a binding energy of −60 kcal/mol or lower, these compounds show a therapeutic effect on a neurodegenerative disease.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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