National University Corporation Hokkaido University
发明人:
申请号：
EP11006919.2
公开号：
EP2407167A2
申请日:
2006.11.17
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
[PROBLEMS] To provide a neuronal cell death inhibitor and a therapeutic agent for a neurodegenerative disease, particularly Perkinson's disease.[MEANS FOR SOLVING PROBLEMS] It is known that DJ―1 protein is involved in Perkinson's disease and is capable of inhibiting neuronal cell death caused by oxidative stress. Based on this knowledge, screening is made for a low molecular weight molecule capable of binding to an active site of DJ―1 protein (i.e., a region around a cysteine residue at position-106) using an analysis softwear FastDock (Fujitsu Ltd.). When various tests are made using candidate low molecular weight compounds each having a binding energy of -60 kcal/mol or lower, these compounds show a therapeutic effect on a neurodegenerative disease.
