An ambidextrous locking clamp system for providing a user the ability to use the right or left hand to engage and disengage a ratcheting means on the clamp. The clamp includes hingedly connected first and second elongated members each with a finger engaging member, a working head, and a latching member featuring ratcheting teeth. The teeth are engaged by moving the finger engaging members toward each other in an engaging motion, and are disengaged by sliding them in a disengaging motion perpendicular to the engaging motion with opposing force applied to the finger engaging members. One of the elongated members includes a planar portion that is rotatably received in a slot defined in a female portion of the other elongated member. The planar portion can include a wedge that contacts a side of the female portion that defines the slot when the clamp is in a closed position.