GIORI, ANDREA,MOMBELLI, GIACOMO,ARPINI, SABRINA,ACERBI, MARIO
申请号：
CA2757925
公开号：
CA2757925C
申请日:
2010.03.31
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Process for removing pesticides from Ginkgo biloba extracts, which involvessubmitting an extract obtained byconventional methods to the following steps: a. Liquid-liquid extraction ofthe extract to obtain a medium polarity fractioncontaining ginkgo terpenes and pesticides not removable with hexane, and ahigh polarity fraction containing ginkgo flavone glycosides；b. crystallisation from the medium polarity fraction obtained at step a) togive an intermediate with a ginkgolide content ofnot less than 50%； c. crystallisation from the residual solution obtained atstep b) to give an intermediate with a bilobalide contentof not less than 50%； d. mixing of the high polarity fraction obtained at stepa) with the ginkgo terpene intermediate and thebilobalide intermediate obtained at steps b) and c).
