The present invention relates to a pharmaceutical composition for preventing or treating a skin disease, comprising a substance specifically binding to a peptide of SEQ ID NO: 1, wherein the substance specifically binding to the peptide of SEQ ID NO: 1 of the present invention, particularly an antibody specifically binding to the peptide of SEQ ID NO: 1 or a binding fragment of said peptide, may be applied to a skin disease expressing the peptide of SEQ ID NO: 1 to effectively prevent and treat the skin disease, and thus the substance may be usefully used as a therapeutic agent for various skin diseases with no known specific causes.
