Jae Wook Yang,Hye Sook Lee,Ji Hyun Lee,Yoon Jin Lee
申请号：
US14979511
公开号：
US09695218B2
申请日:
2015.12.27
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A pharmaceutical composition for preventing or treating an ocular surface disease is disclosed, wherein the pharmaceutical composition includes, as an active component, collagen type II α1 based peptide SEQ ID NO: 2 isolated from chondrocyte-derived extracellular matrix (CDEM). In an alkaline burn animal mode treated with peptide SEQ ID NO: 2, the occurrence of corneal opacification is reduced as well as the expression of angiogenic factors. In addition, the expression of inflammatory markers is reduced while the expression of inflammation-inducing factor is suppressed. The peptide SEQ ID NO: 2 may be applied to a pharmaceutical composition for preventing or treating an ocular surface disease.
