The present disclosure relates to a composition for external application for skin containing a solute which is a benzoic acid amide compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof and a first solubilizer which is one or more of diethylene glycol monoethyl ether, methyl gluceth, glyceryl ether, polyethylene glycol, and polyethylene glycol/polypropylene glycol copolymer, and it provides a composition for external application for skin improved in solubility and feel of use.本揭露關於一種包括一溶質的皮膚外用組合物,該溶質為一苯甲酸醯胺化合物、該化合物之同分異構物、該化合物之藥學上可接受的鹽、該化合物之水合物、或是該化合物之溶劑化物;以及一第一增溶劑,其為二乙二醇單乙醚(diethylene glycol monoethyl ether)、甲基葡糖醇聚醚(methyl gluceth)、甘油醚(glyceryl ether)、聚乙二醇(polyethylene glycol)、以及聚乙二醇/聚丙二醇之共聚合物(polyethylene glycol/polypropylene glycol copolymer)的一或多者,且本揭露提供一種改良的溶解度及使用感之皮膚外用組合物。
