MOSCHWITZER, JAN P,KET, ALDO,DINTER-HEIDORN, HEIKE
申请号：
NZ58836909
公开号：
NZ588369A
申请日:
2009.04.21
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a thermostable solid composition comprising at least one permeability improving substance selected from the group consisting of: polyethylene glycol, propylene glycol, glycerin, an oil, glycofurol, propylene glycol dicaprylate or dicaprate, glyceryl caprylate or caprate, oleic acid, ethoxydiglycol, and poloxamer block copolymers, polysorbates, sorbitan esters, poloxamer block copolymers, hydrogenated castor oil, caprylocaproyl macrogol-8 glycerides, sodium lauryl sulfate, dioctyl sulfosuccinate, polyethylene lauryl ether, ethoxydiglycol, propylene glycol monocaprylate, propylene glycol mono-di-caprylate, propylene glycol dicarpylate or dicparate, glyceryl monocaprylate, glyceryl mono-di-caprylate, caprylocaproyl macrogolglycerides like PEG caprylic or capric glycerides, glyceryl 15 fatty acids (C8 -C18) ethoxylated, oleic acid, linoleic acid, glyceryl monooleate, glyceryl monolaurate, caprylic or capric triglycerides, ethoxylated nonylphenols, lecithin, said permeability improving substance(s) being embedded in a water soluble matrix, with the proviso that said thermostable solid composition does not contain an active pharmaceutical ingredient. Pharmaceutical compositions comprising two phases wherein one phase comprises an active ingredient and the other phase comprises the thermostable solid composition are also disclosed.
