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2,4-Pyrimidinediamine compounds for use in methods to treat or prevent autoimmune diseases
专利权人:
RIGEL PHARMACEUTICALS; INC.
发明人:
SINGH, RAJINDER,ARGADE, ANKUSH,PAYAN, DONALD G.,CLOUGH, JEFFREY,KEIM, HOLGER,SYLVAIN, CATHERINE,LI, HUI,BHAMIDIPATI, SOMASEKHAR
申请号:
ES10010732
公开号:
ES2445208T3
申请日:
2003.07.29
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of formula (Ia) or a salt thereof, in which: R5 is selected from the group consisting of halogen, halogen, -ORd, -SRd, haloalkyloxy (C1-C3), perhaloalkyloxy (C1-C3), - NRcRc, halo (C1-C3) alkyl, perhaloalkyl (C1-C3), -CN, -NC, -OCN, -SCN, -NO, -NO2, -N3, -S (O) Rd, -S (O) 2Rd , - S (O) 2ORd, -S (O) NRcRc; -S (O) 2NRcRc, -OS (O) Rd, -OS (O) 2Rd, -OS (O) 2ORd, -OS (O) NRcRc, -OS (O) 2NRcRc, -C (O) Rd, - C (O) ORd, -C (O) NRcRc, -C (NH) NRcRc, -OC (O) Rd, -SC (O) Rd, -OC (O) ORd, -SC (O) ORd, -OC (O) NRcRc, -SC (O) NRcRc, - OC (NH) NRcRc, -SC (NH) NRcRc, - [NHC (O)] nRd, - [NHC (O)] nORd, - [NHC (O) ] nNRcRc and - [NHC (NH)] nNRcRc, aryl (C5-C10) optionally substituted with one or more of the same R8 or different groups, arylalkyl (C6-C16) optionally substituted with one or more of the same R8 groups or different, 5-10 member heteroaryl optionally substituted with one or more of the same R8 or different groups, and 6-16 member heteroarylalkyl optionally substituted with one or more of the same R8 or different groups, (C1-C6) alkyl optionally substituted with one or more of the same R8 or different groups, (C1-C4) alkanyl optionally substituted with one or more of the same R8 or different groups, alkenyl (C2-C4) optionally substituted with one or more of the same R8 groups or different, and alkynyl (C2-C4) optionally substituted with one or more of the same R8 or different groups; each R6 is independently selected from the group consisting of hydrogen, halogen, -ORd, -SRd, haloalkyloxy (C1-C3), perhaloalkyloxy (C1-C3), -NRcRc, haloalkyl (C1-C3), perhaloalkyl (C1-C3) , -CN, -NC, -OCN, -SCN, -NO, - NO2, -N3, -S (O) Rd, -S (O) 2Rd, -S (O) 2ORd, -S (O) NRcRc; -S (O) 2NRcRc, -OS (O) Rd, -OS (O) 2Rd, -OS (O) 2ORd, -OS (O) NRcRc, - OS (O) 2NRcRc, -C (O) Rd, - C (O) ORd, -C (O) NRcRc, -C (NH) NRcRc, -OC (O) Rd, -SC (O) Rd, -OC (O) ORd, -SC (O) ORd, - OC (O) NRcRc, -SC (O) NRcRc, -OC (NH) NRcRc, -SC (NH) NRcRc, - [NHC (O)] nRd, - [NHC (O)] nORd, - [NHC (O) ] nNRcRc an
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