BAUMANN, Ernst,POHLMAN, Matthias,CLARK, Jeffrey Norman,POWELL, Kerrie Maria,BOECKH, Albert,SOLL, Mark David
申请号：
ES08864594
公开号：
ES2584930T3
申请日:
2008.12.11
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound of 6-halogen [1,2,4] -triazolo [1,5-a] -pyrimidine of the general formula I ** Formula ** in which X is halogen； R1 is hydrogen, halogen, OH, CN, C1-C10 alkyl, C1-C10 haloalkyl, C1-C10 alkoxy, C1-C6 alkoxy-C1-C6 alkyl, C1-C4 alkoxy-C1-C4 alkoxy, C1-C4 alkoxy C1-C4 alkoxy-C1-C4 alkoxy, C1-C10 alkylthio, C1-C10-sulfinyl alkyl, C1-C10-sulfonyl alkyl, C1-C10-amino alkyl, di (C1-C10 alkyl) amino, C2-C10 alkenyl, phenyl, phenoxy, benzyloxy, C2-C10 alkenyloxy, C2-C10 alkynyloxy or C2-C10 alkynyl, wherein C1-C10 alkylthio, C1-C10 alkyl sulfinyl and C1-C10 alkyl sulfonyl may be unsubstituted or partially or completely substituted with halogen, C1-C4 alkoxy, C1-C4 alkoxycarbonyl or COOH； R2 is C1-C10 alkyl, C1-C10 haloalkyl, C1-C6 alkoxy-C1-C6 alkyl, C3-C10 cycloalkyl, C2-C10 alkenyl or C2-C10 alkynyl； R3 is hydrogen, C1-C10 alkyl, C1-C10 haloalkyl, C1-C6 alkoxy-C1-C6 alkyl, C1-C10 alkylcarbonyl, C1-C10 alkoxycarbonyl or arylcarbonyl； A is a single bond or a C1-C6 alkylene chain, in which a methylene group may be substituted with a heteroatom selected from oxygen or sulfur； R4 is C3-C10 cycloalkyl, phenyl, naphthyl, or 3- to 7-membered heterocyclyl, which is unsubstituted or substituted with 1, 2 or 3 radicals that are selected from the group consisting of halogen, cyano, nitro, hydroxy, C1 alkyl -C10, C1-C10 alkoxy, C1-C10 haloalkyl, C1-C10 haloalkoxy, amino, C1-C10 alkyl-amino, di (C1-C10 alkyl) amino, C1-C10 alkylthio, C1-C10 alkyl-sulfinyl, C1 alkyl -C10-sulfonyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl-C1-C4 alkyl, phenyl, phenyl-C1-C4 alkoxy and phenyloxy, in which the last five radicals mentioned on the other hand may be unsubstituted or may carry one , two or three substituents that are selected from the group consisting of C1-C4 alkyl, C1-C4 alkoxy and halogen, and wherein the 3- to 7-membered heterocyclyl contains 1, 2 or 3 heteroatoms selected from the group consisting of oxygen , sulfur, nitrogen and an NRa group, it being also possible that C3-C10 cycloalkyl,
