Compound according to structural formula (V): including salts, hydrates, solvates and N-oxides thereof, in which: R2 is selected from the group consisting of aryl (C5-C15) optionally substituted with one or more of the R8 groups same or different, and 5-15 membered heteroaryl optionally substituted with one or more of the same or different R8 groups； R4 is each W is, independently of the other, -CR31R31-； X is selected from the group consisting of -N- and -CH-； Y and Z are each independently selected from each other from the group consisting of -O-, -S-, -SO-, -SO2-, - SONR36-, -NH-, and -NR35-； R5 is selected from the group consisting of hydrogen, -ORd, -SRd, haloalkyloxy (C1-C3), perhaloalkyloxy (C1-C3), -NRcRc, halogen, haloalkyl (C1-C3), perhaloalkyl (C1-C3), - CN, -NC, -OCN, -SCN, -NO, -NO2, -N3, -S (O) Rd, - S (O) 2Rd, -S (O) 2ORd, -S (O) NRcRc； -S (O) 2NRcRc, -OS (O) Rd, -OS (O) 2Rd, -OS (O) 2ORd, -OS (O) NRcRc, -OS (O) 2NRcRc, - C (O) Rd, - C (O) ORd, -C (O) NRcRc, -C (NH) NRcRc, -OC (O) Rd, -SC (O) Rd, -OC (O) ORd, -SC (O) ORd, -OC (O) NRcRc, - SC (O) NRcRc, -OC (NH) NRcRc, -SC (NH) NRcRc, - [NHC (O)] nRd, - [NHC (O)] nORd, - [NHC (O) ] nNRcRc and - [NHC (NH)] nNRcRc, aryl (C5-C10) optionally substituted with one or more of the same or different R8 groups, arylalkyl (C6-C16) optionally substituted with one or more of the same R8 groups or different, 5-10 membered heteroaryl optionally substituted with one or more of the same or different R8 groups and 6 to 16 membered heteroarylalkyl optionally substituted with one or more of the same or different R8 groups, optionally substituted (C1-C6) alkyl with one or more of the same or different R8 groups, (C1-C4) alkanyl optionally substituted with one or more of the same or different R8 groups, (C2-C4) alkynyl optionally substituted with one or more of the same R8 groups or different and alkenyl (C2-C4) optionally substituted with one or more of the same or different R8 groups； R6 is independently selected from the
