Kari Alitalo,Simo Syrjala,Karl Lemstrom,Ching Ching Leow,Ronald Herbst,Jane Connor
申请号：
US15820943
公开号：
US10400035B2
申请日:
2017.11.22
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The disclosure is directed to methods and uses of antibodies or antigen-binding fragments thereof against Angiopoietin-2 (Ang-2). Specifically, the disclosure is direct to the use of anti-Ang2 antibodies or antigen-binding fragments thereof for treating ischemia. The methods disclosed are useful for reducing microvascular permeability, increasing microvascular perfusion, reducing inflammation in a tissue, and treating or ameliorating diseases associated with ischemia and/or reperfusion injury. The disclosed methods are also useful for protecting solid organ transplant tissue and treating or preventing chronic tissue transplant rejection.
