Kari Lemstrom;Simo Syrjala;MedImmune, LLC;Kari Alitalo
发明人:
Alitalo, Kari,Syrjala, Simo,Lemstrom, Kari,Leow, Ching Ching,Herbst, Ronald,Connor, Jane
申请号：
AU2013230750
公开号：
AU2013230750A1
申请日:
2013.03.07
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The disclosure is directed to methods and uses of antibodies or antigen-binding fragments thereof against Angiopoietin-2 (Ang-2). Specifically, the disclosure is direct to the use of anti-Ang2 antibodies or antigen-binding fragments thereof for treating ischemia. The methods disclosed are useful for reducing microvascular permeability, increasing microvascular perfusion, reducing inflammation in a tissue, and treating or ameliorating diseases associated with ischemia and/or reperfusion injury. The disclosed methods are also useful for protecting solid organ transplant tissue and treating or preventing chronic tissue transplant rejection.
