Karl M. LEMSTROM;Simo SYRJALA;MEDIMMUNE, LLC;Kari ALITALO
发明人:
Kari Alitalo,Simo Syrjala,Karl Lemstrom,Ching Ching Leow,Ronald Herbst,Jane Connor
申请号：
US14383377
公开号：
US20150044227A1
申请日:
2013.03.07
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The disclosure is directed to methods and uses of antibodies or antigen-binding fragments thereof against Angiopoietin-2 (Ang-2). Specifically, the disclosure is direct to the use of anti-Ang2 antibodies or antigen-binding fragments thereof for treating ischemia. The methods disclosed are useful for reducing microvascular permeability, increasing microvascular perfusion, reducing inflammation in a tissue, and treating or ameliorating diseases associated with ischemia and/or reperfusion injury. The disclosed methods are also useful for protecting solid organ transplant tissue and treating or preventing chronic tissue transplant rejection.
