The present invention relates to an ophthalmic nanoemulsion composition and a method for preparing the same which increases the solubility of cyclosporine as an active ingredient and improves the stability of the ophthalmic composition by mixing cyclosporine, a nonaqueous solvent, an emulsifier, and an aqueous solvent, and a method for preventing or treating dry eye syndrome using the same. The ophthalmic nanoemulsion composition according to the present invention is characterized by having an average particle size of 200 nm or less, preferably 100 nm or less, and having a very narrow particle distribution. Therefore, sterilizing filtration is available, stability is improved and has superior effect in clinical enhancement of foreign body sensation and visual disturbance, and thus the ophthalmic nanoemulsion composition of the present disclosure can be effectively used as an ophthalmic composition.본 발명은 사이클로스포린, 비수성용제, 유화제, 수성용제를 혼합함으로써 유효성분인 사이클로스포린의 용해도를 증가시키고 점안 조성물의 안정성을 개선시킨 나노에멀젼 점안조성물 및 이의 제조방법에 관한 것이다. 본 발명에 따른 나노에멀젼 점안조성물은 평균 입자 크기가 200nm 이하 바람직하게는 100nm 이하이며, 입자 분포가 매우 좁은 특징이 있다. 따라서, 제균여과가 가능하고 안정성이 개선되며 임상적으로 이물감 및 시야흐림 개선효과가 우수하므로 안구 점안용으로 유용하게 사용될 수 있다.
