By using a water-soluble polymeric binder, a solid molded body first disintegrant and poorly water-soluble active ingredient and water-soluble excipients, for example, preparing the granules, mixed with a second disintegrant and the solid molded body and a solid molded body disintegrant poorly water-soluble active ingredient and is prepared by using a water-soluble polymeric binder sugar alcohol, or a mixed material obtained by disintegration good poorly water-soluble active ingredient-containing oral I will provide a formulation. It is possible that when orally administered, shows a dissolution profile comparable between formulations the content of the active ingredient varies and is excellent in dissolution of the active ingredient within the gastrointestinal tract, the formulation is most suitable depending on the individual patient to allow for the selection of the drug was, it is very useful clinically.水溶性高分子結合剤を用いて、水難溶性有効成分と第一崩壊剤および水溶性賦形剤との固体成形体、例えば造粒物を調製し、この固体成形体と第二崩壊剤と混合して得られる混合物からなるか、あるいは水難溶性有効成分と崩壊剤および糖アルコールから水溶性高分子結合剤を用いて調製される固体成形体からなる、崩壊性が良好な水難溶性有効成分含有経口製剤を提供する。該製剤は経口投与された場合に、消化管内での有効成分の溶出性に優れ、かつ有効成分の含量が異なる製剤間で同等の溶出挙動を示すことができ、個々の患者に応じて最も適した薬剤の選択を可能にし、臨床上極めて有用である。
