Procedures for Metabolic Disorders, including diabetes, using a combination of an Analogue of acilado glucagon and insulin Analogue. Kit includes a acilado Analogue of glucagon and insulin Analogue.Claim 1: a combination of compounds for use in a procedure to prevent or reduce weight gain； promote Weight Loss, improve the levels of circulating Glucose.Glucose tolerance or circulating cholesterol levels, reduce the levels of circulating LDL, increase HDL / LDL ratio, or produced, or treat a condition characterized by excess body weight, in which the method includes administering to a Mammalian subject a com Combination of compounds.Comprising: (a) a compound having the formula: R1 - R2 Z - in which R1 is H, c1-4 alkyl, Formilo, acetyl, Benzoyl, or trifluoroacetilo； R2 is Oh or NH2； and Z is a Peptide that has the formula: his - X2 - Gln Gly THR - Phe - Thr - - - - - be ASP Tyr Leu ASP Tyr X12 - - - - - - x16 x17 X20 X21 - ala ala PHE Val x24 - t MOP - Leu - - x27 X28 ala X30 the x2 is selected from AIB and X12； select between Lys, ARG,Or choose between ARG leu； x16 and X； X is selected from Arg and x17； select between X20 X21 and x ARG, his, ASP and Glu are selected among； x24 is selected between wing and X27 X； X is selected between Leu and ARG； X28 Selects between X30 X and X； or is absent； At least one of X1 6 x17, x20, X24, x27,X28 and X30 X； X and each other independently selected among the group consisting of Glu, Lys, ser, CYS, dBu, DPR and Orn； in which the side chain of at least one other X is conjugated with a lipophilic Substituent has the formula: (i) Z1, the Z1 is a rest lip u00f3 Edge directly conjugated with the side chain of X； or (ii) z1z2, where Z1 is a lipophilic Rest,Z1 and Z2 is a Spacer is conjugated with the side chain of X through Z2； and (b) an insulin Analogue.Procedimientos para tratar trastornos metabólicos, incluyendo diabetes, mediante el uso de una combinación de un análogo de glucagón acilado y un análogo de insulina. Kit que incluye
