Antibodies with improved effector function

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专利权人:

株式会社医学生物学研究所

发明人:

辻 孝,梶原 康宏,手塚 克成,南部 由利,深江 一博,朝井 洋明,喜多 祥一,瀬戸 美苗,村上 昭弘

申请号：

JP2007267207

公开号：

JP5427348B2

申请日:

2007.10.12

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

<；P>；PROBLEM TO BE SOLVED: To provide an antibody improved in an effector function, a method for simply producing the antibody, a method for improving the effector function of an antibody, and a therapeutic composition which contains the antibody, has a high pharmacological activity, can reduce dosages with less side effects, and can be used for wide-ranging uses. <；P>；SOLUTION: This antibody whose 295-amino acid in the EU index number of Kabat is replaced with a cysteine residue comprises (1) a mutein antibody whose amino acids at specific positions are replaced by other amino acids, and/or (2) an antibody in which the fucose molecules of sugar chains bound to the antibody are reduced. <；P>；COPYRIGHT: (C)2009,JPO&INPIT

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