ГАО Цзян (DE),ФИШЛЕР Моника (DE),ЭРДМАНН Фолькер А. (DE)
申请号：
RU2012129977/10
公开号：
RU2012129977A
申请日:
2010.12.16
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. An active substance release system comprising i) a composition 1 containing at least one nanoparticle bound to an inhibitor oligonucleotide filament, wherein the inhibitor oligonucleotide filament is hybridized with a catalytically active nucleic acid, and ii) a composition 2 containing a carrier bound to at least one a substrate molecule, wherein the substrate molecule is bound to at least one therapeutic active substance, wherein the therapeutic active substance can be released by epleniya substrate molecule, wherein cleavage of the substrate molecule occurs via the catalytically active nucleic kisloty.2. The active substance release system according to claim 1, wherein the inhibitor oligonucleotide filament is covalently, in particular, bonded to compound 1 through compound 1. The active substance release system according to one of claims 1 to 2, wherein the catalytically active nucleic acid is selected from the group consisting of RNA, DNA, L-RNA, L-DNA and a modified nucleic acid, in particular containing an SH-modified nucleotide preferably with a length of from 10 to 100 nucleotides, in particular with a length of 12 to 60 nucleotides, the catalytically active nucleic acid being preferably RNA, in particular a ribozyme, in particular a Hammerhead type ribozyme, in particular having sequence 5 '-GGC UCG ACU GAU GAG GCG C-3' (SEQ ID NO: 1). 4. The active substance release system according to claim 3, wherein compound 1 is formed by the reaction of amino groups with transverse compounds and SH groups of SH-modified nucleotides at the 5'-end of the oligonucleotide filament and�1. Система высвобождения действующего вещества, содержащаяi) композицию 1, содержащую по меньшей мере одну наночастицу, связанную с олигонуклеотидной нитью ингибитора, причем олигонуклеотидная нить ингибитора гибридизована с каталитически активной нуклеиновой кислотой, иii) композицию 2, содержащую носитель, связанный с по меньшей мере одной молекулой субстрата, причем молекула субстрата
