AQUINO, CHRISTOPHER JOSEPH,COLLINS, JON LOREN,COWAN, DAVID JOHN,WU, YULIN
申请号：
PE0020822012
公开号：
PE03842013A1
申请日:
2011.04.27
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to a compound benzotiazepina Derivatives of formula (i) wherein R1 is H, BR, CL, N (CH3) 2 or methoxyl R2 is H or Oh R3 is C1 - C6 alkyl R4 is - SO3H, CO2H PO3H2, among others X is CH2, C (o) or CH = CH Q is absent or c1-c6 alkyl.Preferred compounds are: (a) 3 - [(3R, 5R) - 3 - butyl - 4 - 7 - ethyl - (metiloxi) - 1,1 - dioxide - 4 - phenyl - 2,3,4,5 - tetrahydro - 1.4 - benzotiazepin - 8 - yl] - N - (Methyl sulfonyl) - propanamide, acid ({3 - [(3R, 5R) - 3 - butyl - 4 - 7 - ethyl - (metiloxi) - 1,1 - dioxide - 4 - phenyl - 2,3,4,5 - tetrahydro - 1.4 - benzotiazepin - il - 8}) - amino] - propanoil put - sulfonic acid among others. Also referred to a Pharmaceutical composition.This Compound is an inhibitor of the ileal bile acid reabsorption (Astb) is useful in the treatment of diabetes mellitus.SE REFIERE A UN COMPUESTO DERIVADOS DE BENZOTIAZEPINA DE FORMULA (I) DONDE R1 ES H, Br, Cl, N(CH3)2 O METOXILO R2 ES H U OH R3 ES ALQUILO C1-C6 R4 ES OH, SO3H, CO2H, PO3H2, ENTRE OTROS X ES CH2, C(O) O CH=CH Q ESTA AUSENTE O ES ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS: (a) 3-[(3R, 5R)-3-BUTIL-3-ETIL-7-(METILOXI)-1,1-DIOXIDO-5-FENIL-2,3,4,5-TETRAHIDRO-1,4-BENZOTIAZEPIN-8-IL]-N-(METIL-SULFONIL)-PROPANAMIDA, ACIDO ({3-[(3R,5R)-3-BUTIL-3-ETIL-7-(METILOXI)-1,1-DIOXIDO-5-FENIL-2,3,4,5-TETRAHIDRO-1,4-BENZOTIAZEPIN-8-IL]-PROPANOIL}-AMINO)-METAN-SULFONICO ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE LA REABSORCION ILEAL DEL ACIDO BILIAR (ASTB) SIENDO UTIL EN EL TRATAMIENTO DE DIABETES MELLITUS.
