A compound of the formula I: R1-L1-A-L2-R2 wherein, A is selected from the group consisting of Ia, Ib or Ic: ** Formula ** wherein, X is N or CH； Y is NH or CH2； or ** Formula ** where, X is NH or CH2； Y is N or CH； or ** Formula ** where L1 is a bond, - (CH2) 1-3-, -NH- (CH2) 0-3-C (O) -, - (CH2) 0-3-C (O) -, - (CH2) 0-3-SO2- or - (CH2) 0-3-NR3-C (O) -； L2 is a bond, - (CH2) 1-3-, -C (O) - (CH2) 0-3-NH-, -NH- (CH2) 0-3-C (O) -NH-, - ( CH2) 0-3-C (O) -, - (CH2) 0-3-SO2-, or - (CH2) 0- 3-NR3-C (O) -； R1 is phenyl, 5- or 6-membered heteroaryl, adamantyl, or - (CH2) 1-3-phenyl, wherein said phenyl, heteroaryl or adamantyl is unsubstituted or substituted by one to three R5； R2 is phenyl, 5- or 6-membered heteroaryl or - (CH2) 1-3-phenyl, wherein said phenyl or heteroaryl is unsubstituted or substituted by one to three R5； R3 is hydrogen or lower alkyl； R 4 is hydrogen or lower alkyl； R5 is halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, or -C (O) OR4, or stereoisomers, tautomers or pharmaceutically acceptable salts thereof, with the exception of (4-bromophenyl) [6 - [(4-methylphenyl) sulfonyl] -1,6-diazaspiro [3,3] hept-1-yl] methanone, and with the proviso that, when L2 is -C (O) -NH-, L1 is not -CH2-, and with the condition that, when L2 is -CH2-, L1 is not a link, and with the condition that, when L2 is -SO2-, L1 is not -CH2- and with the condition that L1 and L2 are different.Un compuesto de la fórmula I: R1-L1-A-L2-R2 en donde, A se selecciona de entre el grupo consistente en Ia, Ib ó Ic:**Fórmula** en donde, X es N ó CH； Y es NH ó CH2； ó**Fórmula** en donde, X es NH ó CH2； Y es N ó CH； ó**Fórmula** en donde L1 es un enlace, -(CH2)1-3-, -NH-(CH2)0-3-C(O)-, -(CH2)0-3-C(O)-, -(CH2)0-3-SO2- ó -(CH2)0-3-NR3-C(O)-； L2 es un enlace, -(CH2)1-3-, -C(O)-(CH2)0-3-NH-, -NH-(CH2)0-3-C(O)-NH-, -(CH2)0-3-C(O)-, -(CH2)0-3-SO2-, ó -(CH2)0- 3-NR3-C(O)-； R1 es fenilo, heteroarilo de 5 ó 6 miembros, adamantilo, ó -(CH2)1-3-fenilo, en donde, dicho fenilo, heteroarilo ó adaman
