ОКСИМЕТИЛЕНАРИЛОВЫЕ СОЕДИНЕНИЯ В КОМБИНАЦИИ С ИНГИБИТОРОМ ДПП 4 (ВАРИАНТЫ) И СПОСОБЫ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С НАРУШЕНИЕМ ГЛИКЕМИЧЕСКОГО КОНТРОЛЯ С ИХ ПОСРЕДСТВОМ (ВАРИАНТЫ)
ДЖОНСОН Джефри (US),КЛЕМЕНС Л., Эдвард (US),УИЛСОН Мария Е. (GB),ЧЖАО Чжухунь (US),ЧЭНЬ Син (CN)
申请号：
RU2010143285/15
公开号：
RU2010143285A
申请日:
2009.03.30
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A method of treating diabetes comprising administering to a patient in dipeptidyl peptidase 4 (DPP 4) and oksimetilenarilovyh compounds encompassed by the general structural formula (I):! ! wherein D is selected from the group consisting of O, S and NR8,! X, Y and Z are independently selected from the group consisting of O, N, NR8, S and CR3, and at least one of X, Y and Z is O, N, NR8 or S,! each of J, K, T and U are independently selected from the group consisting of C, CH and N,! the subscript p is an integer from 0 to 4! the subscript q is an integer from 0 to 4! R1 represents a substituent selected from the group consisting of H, C1-10alkyl, S1-10zameschenny alkyl, C3-7 cycloalkyl, S2-10alkenil, S2-10alkinil, -X1SORa, -X1CO2Ra, -X1CONRaRb, -SO2Ra, 4-7-membered heterocyclic group, aryl, and a 5-10 membered heteroaryl group, wherein each of said cycloalkyl, heterocyclyl, aryl and heteroaryl groups optionally substituted with 1-4 substituents independently selected from halo, C1-10alkyl, S1-10zameschennogo alkyl, C3-7cycloalkyl, S2-10alkenila, S2-10alkinila, aryl, heteroaryl, -CN, -NRaCORb, -NRaCONRaRb, -NO2, -ORa, -NRaRb, -CORa, -CO2Ra, -CONRaRb, -S (O) mRa, - NRaS (O) 2Rb and -SO2NRaRb, or optionally Ra and Rb together form a 4-, 5- or 6-membered ring, and X1 is selected from the group consisting of bond, C2-6alkyl, C2-6alkynyl, -C (O) - and -C (O) - (CH2) 1-4-, wherein X1 aliphatic portion is optionally substituted with one to three substituents selected from halo, C1-4alkyl, alkyl and S1-4zameschennogo S1-4galoalkila,! each R2 is a substituent selected independently from the group consisting of halogen, C 1-5 alkyl, S1-5zameschenny alkyl, C3-7 cycloalkyl, -CORa, -CO2Ra, -CONRaRb, -ORa, -NRaRb, -NRaCORb, -SORaRb, -SO2Ra and -SO2NRaRb and where, if the subscript q is 2
