As for this invention, being the bird influenza virus vaccine which includes the liposome which peptide connects,The said peptide, implication the amino acid arrangement to which 1 or 2 amino acids are substituted (1) arrangement number the amino acid arrangement which is displayed with either 1 - 9, or (2) arrangement number at the time of amino acid arranging which is displayed 1 - 9 with in each case,To possess the length of 9 - 11 amino acids, at the same timeIt is something which can induce the cell injury characteristic T lymphocyte which is restrained to HLAThe said liposome, the carbon count the carbon count contains the stabilization medicine of the phosphatide, and the liposome where has 14 which the acyl basis or unsaturated bond of 14 which unsaturated bond 1 characteristics is done - 24 1 characteristics is done - 24 the hydrocarbon radical At the same timeThe said peptide has connected to the surface of the said liposome,The bird influenza virus vaccine is offered.本発明は、ペプチドが結合したリポソームを含む鳥インフルエンザウイルスワクチンであって、該ペプチドが、(1)配列番号1~9のいずれかで表されるアミノ酸配列、又は(2)配列番号1~9のいずれかで表されるアミノ酸配列において、1又は2個のアミノ酸が置換されたアミノ酸配列を含み、9~11アミノ酸の長さを有し、且つHLAに拘束された細胞傷害性Tリンパ球を誘導し得るものであり;該リポソームが、不飽和結合を1個有する炭素数14~24のアシル基又は不飽和結合を1個有する炭素数14~24の炭化水素基を有するリン脂質、及びリポソームの安定化剤を含有し;且つ該リポソームの表面に該ペプチドが結合している、鳥インフルエンザウイルスワクチンを提供する。
